Neue Viruserkrankungen

The general area of our research is the immunobiology of infection of ssRNA viruses with a special focus on influenza A virus and filoviruses. We are particularly interested in defining the mechanisms utilized by dendritic cells (DCs) for T cell priming, as well as the sub-specialization of DC subsets in the antiviral response. The lessons learned in these basic studies are used to develop new vaccines for the treatment of emerging viral diseases.

Recent publications

Muñoz-Fontela C, Pazos M, Delgado I, Murk W, Mungamuri SK, Lee SW, García-Sastre A, Moran TM, Aaronson SA. (2011). p53 Serves as a Host Antiviral Factor That Enhances Innate and Adaptive Immune Responses to Influenza A Virus. J Immunol. Nov 21. [Epub ahead of print]

Muñoz-Fontela C, González D, Marcos-Villar L, Campagna M, Gallego P, González-Santamaría J, Herranz D, Gu W, Serrano M, Aaronson SA, Rivas C. (2011). Acetylation is indispensable for p53 antiviral activity. Cell Cycle. Nov 1; 10(21). [Epub ahead of print]

Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. (2008). Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med. Aug 4;205(8):1929-38.

Abteilungen & Forschungsgruppen