Emerging Viruses
The general area of our research is the immunobiology of infection of ssRNA viruses with a special focus on influenza A virus and filoviruses. We are particularly interested in defining the mechanisms utilized by dendritic cells (DCs) for T cell priming, as well as the sub-specialization of DC subsets in the antiviral response. The lessons learned in these basic studies are used to develop new vaccines for the treatment of emerging viral diseases.
Aktuelle Publikationen
Marcos-Villar L, Gallego P, Muñoz-Fontela C, de la Cruz-Herrera CF, Campagna M, González D, Lopitz-Otsoa F, Rodríguez MS, Rivas C. (2013). Kaposi's sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation. Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.603. [Epub ahead of print]
Brown-Endres L, Schoenfeld D, Tian F, Kim HG, Namba T, Muñoz-Fontela C, Mandinova A, Aaronson SA, Lee SW (2012). Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells. Cancer Res 72(9):2373-82.
Pazos MA, Kraus TA, Muñoz-Fontela C, Moran TM (2012). Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice. PLoS One 7(7):e40502. Epub 2012 Jul 5.
Recent Publications
Muñoz-Fontela C, Pazos M, Delgado I, Murk W, Mungamuri SK, Lee SW, García-Sastre A, Moran TM, Aaronson SA. (2011). p53 Serves as a Host Antiviral Factor That Enhances Innate and Adaptive Immune Responses to Influenza A Virus. J Immunol. Nov 21. [Epub ahead of print]
Muñoz-Fontela C, González D, Marcos-Villar L, Campagna M, Gallego P, González-Santamaría J, Herranz D, Gu W, Serrano M, Aaronson SA, Rivas C. (2011). Acetylation is indispensable for p53 antiviral activity. Cell Cycle. Nov 1; 10(21). [Epub ahead of print]
Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA. (2008). Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med. Aug 4;205(8):1929-38.
Departments and Research Groups
Neue Viruserkrankungen
Leiter
Dr. Cesar Munoz-Fontela
Martinistraße 52
20251 Hamburg
Phone: 040/48051-280
