Scientific HPI Publications on COVID-19 (SARS-CoV-2)

Peer-reviewed or reviews:

Bunders M, Altfeld M (2020). Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic intervention. REVIEW: Immunity. 2020 Sep 15;53(3):487-495.

Günther T, Czech-Sioli M, Indenbirken D, Robitaille A, Tenhaken P, Exner M, Ottinger M, Fischer N, Grundhoff A, Brinkmann MM (2020). SARS-CoV-2 outbreak investigation in a German meat processing plant. EMBO Mol Med. 2020 Oct 4:e202013296.

Mousavizadeh L, Ghasemi S (2020). Genotype and phenotype of COVID-19: Their roles in pathogenesis. J Microbiol Immunol Infect. 2020 Mar 31.

Pfefferle S, Guenther T, Kobbe R, Czech-Sioli M, Noerz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch J, Luetgehetmann M, Fischer N (2021). SARS-CoV-2 variant tracing within the first COVID-19 clusters in Northern Germany. Clin Microbiol Infect. 2021 Jan;27(1):130.e5-130.e8.

Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N (2020). Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany. Microbiol Resour Announc. 2020 Jun 4;9(23):e00520-20.

Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M (2020). A molecular pore spans the double membrane of the coronavirus replication organelle. Science. 2020 Aug 6:eabd3629.

Preprints:

Guenther S, Reinke PYA, Fernandez-Garcia Y, Lieske J, Lane TJ, Ginn H, Koua F, Ehrt C, Ewert W, (…), Krichel B, Kopicki J, (…), Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Guenther S, (...), Pearson AR, Betzel C, Meents (2020). Inhibition of SARS-CoV-2 main protease by allosteric drug-binding. bioRxiv [Preprint] 2020.11.12.378422; doi: https://doi.org/10.1101/2020.11.12.378422

Günther S, Reinke PYA,  Fernández-García Y, (…), Krichel B, Kopicki JD, (…), Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson Ar, Betzel X, Meents A (2020). Massive X-ray screening reveals two allosteric drug binding sites of SARS-CoV-2 main protease. bioRxiv [Preprint] 2020.11.12.378422; doi: https://doi.org/10.1101/2020.11.12.378422

Günther S, Reinke PYA, Oberthuer D, (...), Schmidt C, Schubert R, Han H, Krichel B, Fernández-García Y, Escudero-Pérez B, Günther A, Turk D, Uetrecht C, (...), Hilgenfeld R, Chapman HN, Pearson AR, Betzel C, Meents A (2020). Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease. bioRxiv [Preprint] 2020.05.02.043554; doi: https://doi.org/10.1101/2020.05.02.043554

Krichel B, Bylapudi G, Schmidt C, Blanchet C, Schubert R, Brings L, Koehler M, Zenobi R, Svergun D, Lorenzen K, Madhugiri R, Ziebuhr J, Uetrecht C (2020). Hallmarks of Alpha - and Betacoronavirus non-structural protein 7+8 complexes. bioRxiv [Preprint] 2020.09.30.320762; doi:  https://doi.org/10.1101/2020.09.30.320762

Malhotra S, Joseph AP, Thiyagalingam J, Topf M (2020). Assessment of protein-protein interfaces in cryo-EM derived assemblies. bioRxiv [Preprint] 2020.11.17.387068; doi: https://doi.org/10.1101/2020.11.17.387068

Pfefferle S, Guenther T, Puelles V, Heinrich F, Noerz D, Czech-Sioli M, Carstens A, Krasemann S, Wong M, Oestereich L, Magnus T, Allweiss L, Edler C, Schroeder AS, Dandri M, Huber T, Glatzel M, Pueschel K, Grundhoff A, Luetgehetmann M, Aepfelbacher M, Fischer N (2020). SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19. bioRxiv [Preprint] 2020.10.10.334458; doi: https://doi.org/10.1101/2020.10.10.334458

Schroeder M, Schaumburg B, Müller Z, Parplys A, Jarczak D, Nierhaus A, Kloetgen A, Schneider B, Peschka M, Stoll F, Bai T, Jacobsen H, Zickler M, Stanelle-Bertram S, de Heer G, Renné T, Meinhardt A, Heeren J, Aberle J, McHardy AC, Schlüter H, Hiller J, Peine S, Kreienbrock L, Klingel K, Kluge S, Gabriel G (2020). Sex hormone and metabolic dysregulations are associated with critical illness in male Covid-19 patients. medRxiv [Preprint] 2020.05.07.20073817; doi: https://doi.org/10.1101/2020.05.07.20073817 

Stanelle-Bertram S, Schaumburg B, Mounogou Kouassi N, Beck S, Zickler M, Beythien G, Becker K, Bai T, Jania H, Müller Z, Pinho dos Reis V, Krump-Buzumkic V, Kadek A, Uetrecht C, Schroeder M, Jarczak D, Nierhaus A, Kluge S, Scaturro P, Baumgärtner W, Klingel K, Gabriel G. SARS-CoV-2 induced CYP19A1 expression in the lung correlates with increased aromatization of testosterone-to-estradiol in male golden hamsters. Research Square [Preprint] 21 November 2020; doi: https://doi.org/10.21203/rs.3.rs-107474/v1

Stukalov A, Girault V, Grass V, Bergant V, Karayel O, Urban C, Haas DA, Huang Y, Oubraham,L Wang A, Hamad SM, Piras A, Tanzer M, Hansen FM, Enghleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A (2020). Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV. BioRxiv [Preprint]; doi: https://doi.org/10.1101/2020.06.17.156455