Scientific HPI Publications on COVID-19 (SARS-CoV-2)

Peer-reviewed or reviews:

2021

Allnoch L, Beythien G, Leitzen E, Becker K, Kaup F-J, Stanelle-Bertram S, Schaumburg B, Mounogou Kouassi N, Beck S, Zickler M, Herder V, Gabriel G, Baumgärtner W. Vascular Inflammation Is Associated with Loss of Aquaporin 1 Expression on Endothelial Cells and Increased Fluid Leakage in SARS-CoV-2 Infected Golden Syrian Hamsters. Viruses. 2021 Apr 8;13(4):639.

Becker K, Beythien G, de Buhr N, Stanelle-Bertram S, Tuku B, Kouassi NM, Beck S, Zickler M, Allnoch L, Gabriel G, von Köckritz-Blickwede M and Baumgärtner W. Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2. Front Immunol. 2021 Apr 12;12:640842.

Brehm TT, Pfefferle S, von Possel R, Kobbe R, Nörz D, Schmiedel S, Grundhoff A, Olearo F, Emmerich P, Robitaille A, Günther T, Braun P, Andersen G, Knobloch JK, Addo MM, Lohse AW, Aepfelbacher M, Fischer N, Schulze Zur Wiesch J, Lütgehetmann M. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. Viruses. 2021 Apr 12;13(4):661.

Garcia G Jr, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication. Cell Rep. 2021 Mar 18:108940.

Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schluenzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. Science. 2021 May 7;372(6542):642-646.

Hambach J, Stähler T, Eden T, Wendt D, Tode N, Haag F, Tolosa E, Altfeld M, Fathi A, Dahlke C, Addo MM, Menzel S, Koch-Nolte F. A simple, sensitive, and low-cost FACS assay for detecting antibodies against the native SARS-CoV-2 spike protein. Immun Inflamm Dis. 2021 May 12.

Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, Glatzel M, Nörz D, Günther T, Czech-Sioli M, Fischer N, Grundhoff A, Lütgehetmann M, Ondruschka B. Dying of VOC-202012/01 - multimodal investigations in a death case of the SARS-CoV-2 variant. Int J Legal Med. 2021 Jun 5:1–10.

Krichel B, Bylapudi G, Schmidt C, Blanchet C, Schubert R, Brings L, Koehler M, Zenobi R, Svergun D, Lorenzen K, Madhugiri R, Ziebuhr J, Uetrecht C. Hallmarks of Alpha- and Betacoronavirus non- structural protein 7+8 complexes. Science Advances. 2021 March 3.

Malhotra S, Joseph AP, Thiyagalingam J, Topf M (2021). Assessment of protein-protein interfaces in cryo-EM derived assemblies. Nat Commun. 2021 Jun 7;12(1):3399.

Mousavizadeh L, Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. J Microbiol Immunol Infect. 2021 Apr;54(2):159-163.

Pfefferle S, Guenther T, Kobbe R, Czech-Sioli M, Noerz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch J, Luetgehetmann M, Fischer N. SARS-CoV-2 variant tracing within the first COVID-19 clusters in Northern Germany. Clin Microbiol Infect. 2021 Jan;27(1):130.e5-130.e8.

Schroeder M, Schaumburg B, Mueller Z, Parplys A, Jarczak D, Roedl K, Nierhaus A, de Heer G, Grensemann J, Schneider B, Stoll F, Bai T, Jacobsen H, Zickler M, Stanelle-Bertram S, Klaetschke K, Renné T, Meinhardt A, Aberle J, Hiller J, Peine S, Kreienbrock L, Klingel K, Kluge S & Gabriel G. High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study. Emerging Microbes & Infections Aug 17, 2021 (accepted author version)

Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Enghleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.

Tallarek AC, Urbschat C, Fonseca Brito L, Stanelle-Bertram S, Krasemann S, Frascaroli G, Thiele K, Wieczorek A, Felber N, Lütgehetmann M, Markert UR, Hecher K, Brune W, Stahl F, Gabriel G, Diemert A, Arck PC. Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy. Front Immunol. 2021 Jun 3;12:698578.

2020

Bunders M, Altfeld M. Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic intervention. REVIEW: Immunity. 2020 Sep 15;53(3):487-495.

Günther T, Czech-Sioli M, Indenbirken D, Robitaille A, Tenhaken P, Exner M, Ottinger M, Fischer N, Grundhoff A, Brinkmann MM. SARS-CoV-2 outbreak investigation in a German meat processing plant. EMBO Mol Med. 2020 Oct 4:e202013296.

Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N. Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany. Microbiol Resour Announc. 2020 Jun 4;9(23):e00520-20.

Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M. A molecular pore spans the double membrane of the coronavirus replication organelle. Science. 2020 Aug 6:eabd3629.

Preprints:

Günther S, Reinke PYA, Oberthuer D, (...), Schmidt C, Schubert R, Han H, Krichel B, Fernández-García Y, Escudero-Pérez B, Günther A, Turk D, Uetrecht C, (...), Hilgenfeld R, Chapman HN, Pearson AR, Betzel C, Meents A. Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease. bioRxiv [Preprint] 2020.05.02.043554; doi: https://doi.org/10.1101/2020.05.02.043554

Pfefferle S, Guenther T, Puelles V, Heinrich F, Noerz D, Czech-Sioli M, Carstens A, Krasemann S, Wong M, Oestereich L, Magnus T, Allweiss L, Edler C, Schroeder AS, Dandri M, Huber T, Glatzel M, Pueschel K, Grundhoff A, Luetgehetmann M, Aepfelbacher M, Fischer N. SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19. bioRxiv [Preprint] 2020.10.10.334458; doi: https://doi.org/10.1101/2020.10.10.334458

Stanelle-Bertram S, Schaumburg B, Mounogou Kouassi N, Beck S, Zickler M, Beythien G, Becker K, Bai T, Jania H, Müller Z, Pinho dos Reis V, Krump-Buzumkic V, Kadek A, Uetrecht C, Schroeder M, Jarczak D, Nierhaus A, Kluge S, Scaturro P, Baumgärtner W, Klingel K, Gabriel G. SARS-CoV-2 induced CYP19A1 expression in the lung correlates with increased aromatization of testosterone-to-estradiol in male golden hamsters. Research Square [Preprint] 21 November 2020; doi: https://doi.org/10.21203/rs.3.rs-107474/v1