Ongoing Projects

Here you will find an overview of current SARS-CoV-2 research projects at HPI:

 

Studies on the pathogenicity and transmissibility of SARS-CoV-2 compared to SARS-CoV, MERS-CoV and influenza in different animal models

Prof. Dr. Gülsah Gabriel (Research Department Viral Zoonosis - One Health)

 

Virus phylogeny & metagenomics of SARS-CoV-2 patient samples | Genetic variability and tissue/cell tropism

Prof. Dr. Adam Grundhoff (Research Unit Virus Genomics)

 

Structure and function of coronaviral replication and transcription complexes by mass spectrometry

Dr. Charlotte Uetrecht (Junior Research Group Dynamics of viral Structures)

 

Light microscopic and electron microscopic examination of SARS-CoV-2 infected samples | Cryo-electron microscopic structural investigations

Prof. Dr. Jens B. Bosse (Assoziierte Group Quantitative Virology)

Prof. Dr. Kay Grünewald (Research Department Structural Cell Biology of Viruses)

 

Research on the immune system to answer the question why the immune system of older people and men copes less well with the disease

Prof. Dr. Marcus Altfeld (Research Department Virus Immunology)

Dr. Dr. Madeleine Altfeld-Bunders (Subunit Immune Ontogeny)

 

Evaluation of antivirals and vaccines against SARS-CoV-2 in animal models

Prof. Dr. Gülsah Gabriel (Research Department Viral Zoonosis - One Health)

 

Rapid Response / Predictive pathogen detection method by mass spectrometry

Dr. Charlotte Uetrecht (Junior Research Group Dynamics of viral Structures)

Dr. Pietro Scaturro (Junior Research Group Systems Arbovirology)

 

Establishment of human organoids from tissue samples of SARS-CoV-2 positive and negative patients | Recognition of the infected organoids by immune cells | Investigation of the immune cell activity

Prof. Dr. Marcus Altfeld (Research Department Virus Immunology)

Dr. Dr. Madeleine Altfeld-Bunders (Subunit Immune Ontogeny)

 

Establishment of a reverse genetics system for cloning and targeted modification of the SARS-CoV-2 genome | Characterization of genetic variants and pathogenicity factors

Prof. Dr. Wolfram Brune (Research Department Virus-Host-Interaction)