Scheme of viral capsid intermediate selection in a quadrupole

Methods

  • state-of-the-art mass spectrometry (MS) techniques: native, ion mobility, TopDown and BottomUp proteomics, hydrogen/deuterium-exchange, labelling, crosslinking
  • classical biochemical and cell biological methods for data verification
  • application of X-ray lasers to biological problems

Recent Publications

Anjanappa R, Garcia-Alai M, Kopicki JD, Lockhauserbäumer J, Aboelmagd M, Hinrichs J, Nemtanu IM, Uetrecht C, Zacharias M, Springer S, Meijers R (2020). Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection. Nat Commun. 2020 Mar 11;11(1):1314.

Heidemann J, Kölbel K, Konijnenberg A, Van Dyck J, Garcia-Alai M, Meijers R, Sobott F, Uetrecht C (2020). Further insights from structural mass spectrometry into endocytosis adaptor protein assemblies. Int. J. Mass Spectrom. 447:116240.

Horstmann JA, Lunelli M, Cazzola H, Heidemann J, Kühne C, Steffen P, Szefs S, Rossi C, Lokareddy RK, Wang C, Lemaire L, Hughes KT, Uetrecht C, Schlüter H, Grassl GA, Stradal TEB, Rossez Y, Kolbe M, Erhardt M (2020). Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion. Nat Commun. 2020 Apr 24;11(1):2013.