Scheme of viral capsid intermediate selection in a quadrupole

Methods

  • state-of-the-art mass spectrometry (MS) techniques: native, ion mobility, TopDown and BottomUp proteomics, hydrogen/deuterium-exchange, labelling, crosslinking
  • classical biochemical and cell biological methods for data verification
  • application of X-ray lasers to biological problems

Recent Publications

Bernal I, Börnicke J, Heidemann J, Svergun D, Horstmann JA, Erhardt M, Tuukkanen A, Uetrecht C, Kolbe M (2019). Molecular Organization of Soluble Type III Secretion System Sorting Platform Complexes. J Mol Biol. 2019 Jul 6.

Bernal I, Römermann J, Flacht L, Lunelli M, Uetrecht C, Kolbe M (2019). Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci. 2019 Aug 8.

Kesgin-Schaefer S, Heidemann J, Puchert A, Koelbel K, Yorke B, Huse N, Pearson AR, Uetrecht C, Tidow H (2019). Crystal structure of a domain-swapped photoactivatable sfGFP variant provides evidence for GFP folding pathway. FEBS J. 2019 Jun;286(12):2329-2340.