Scheme of viral capsid intermediate selection in a quadrupole

Methods

  • state-of-the-art mass spectrometry (MS) techniques: native, ion mobility, TopDown and BottomUp proteomics, hydrogen/deuterium-exchange, labelling, crosslinking
  • classical biochemical and cell biological methods for data verification
  • application of X-ray lasers to biological problems

Recent Publications

Bernal I, Börnicke J, Heidemann J, Svergun D, Horstmann JA, Erhardt M, Tuukkanen A, Uetrecht C, Kolbe M (2019). Molecular Organization of Soluble Type III Secretion System Sorting Platform Complexes. J Mol Biol. 2019 Sep 6;431(19):3787-3803.

Bernal I, Römermann J, Flacht L, Lunelli M, Uetrecht C, Kolbe M (2019). Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci. 2019 Oct;28(10):1888-1901.

Dülfer J, Kadek A, Kopicki JD, Krichel B, Uetrecht C (2019). Structural mass spectrometry goes viral. Adv Virus Res. 2019;105:189-238.