Methods

    • next generation sequencing/NGS (Illumina platform)  und microarray analysis (Agilent platform)
    • development and application of bioinformatic methods for the detection and analysis of viral agents by next generation sequencing or microarray analysis 
    • analysis of viral and cellular chromatin (ChIP-on-chip, ChIP-seq)
    • transcriptomics, analysis of transcription profiles via RNA-seq
    • all current molecular biology nucleic acids and protein methods
    • cultivation of established cell lines and primary cells
    • infection models of various Herpes- and Polyomaviruses
    • manipulation of complex viral genomes by bacmid technology
    • gene transfer by viral and non-viral systems
    • real-time PCR (DNA/ RNA)
    • fluorescence and light microscopy
    • FACS-analysis
    • Infection Model Systems of different Herpes- and Polyomaviruses

    Recent Publications

    Bossler F, Kuhn BJ, Günther T, Kraemer SJ, Khalkar P, Adrian S, Lohrey C, Holzer A, Shimobayashi M, Dürst M, Mayer A, Rösl F, Grundhoff A, Krijgsveld J, Hoppe-Seyler K, Hoppe-Seyler F (2019). Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling. MBio. 2019 Feb 12;10(1).

    Chemnitz J, Pieper D, Stich L, Schumacher U, Balabanov S, Spohn M, Grundhoff A, Steinkasserer A, Hauber J, Zinser E (2019). The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice. Sci Rep. 2019 Mar 19;9(1):4853.

    Fux R, Arndt D, Langenmayer MC, Schwaiger J, Ferling H, Fischer N, Indenbirken D, Grundhoff A, Dölken L, Adamek M, Steinhagen D, Sutter G (2019). Piscine Orthoreovirus 3 Is Not the Causative Pathogen of Proliferative Darkening Syndrome (PDS) of Brown Trout (Salmo trutta fario). Viruses. 2019 Jan 28;11(2).