Methods

    • next generation sequencing/NGS (Illumina platform)  und microarray analysis (Agilent platform)
    • development and application of bioinformatic methods for the detection and analysis of viral agents by next generation sequencing or microarray analysis 
    • analysis of viral and cellular chromatin (ChIP-on-chip, ChIP-seq)
    • transcriptomics, analysis of transcription profiles via RNA-seq
    • all current molecular biology nucleic acids and protein methods
    • cultivation of established cell lines and primary cells
    • infection models of various Herpes- and Polyomaviruses
    • manipulation of complex viral genomes by bacmid technology
    • gene transfer by viral and non-viral systems
    • real-time PCR (DNA/ RNA)
    • fluorescence and light microscopy
    • FACS-analysis
    • Infection Model Systems of different Herpes- and Polyomaviruses

    Recent Publications

    Brehm TT, Pfefferle S, von Possel R, Kobbe R, Nörz D, Schmiedel S, Grundhoff A, Olearo F, Emmerich P, Robitaille A, Günther T, Braun P, Andersen G, Knobloch JK, Addo MM, Lohse AW, Aepfelbacher M, Fischer N, Schulze Zur Wiesch J, Lütgehetmann M (2021). SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. Viruses. 2021 Apr 12;13(4):661.

    Hamann MV, Ehmele P, Verdikt R, Bialek-Waldmann JK, Virdi S, Günther T, Van Lint C, Grundhoff A, Hauber J, Lange UC (2021). Transcriptional Behavior of the HIV-1 Promotor in Contect of the BACH2 Prominent Proviral Integration gene. Virus Res. 2021 Feb;293:198260.

    Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, Glatzel M, Nörz D, Günther T, Czech-Sioli M, Fischer N, Grundhoff A, Lütgehetmann M, Ondruschka B (2021). Dying of VOC-202012/01 - multimodal investigations in a death case of the SARS-CoV-2 variant. Int J Legal Med. 2021 Jun 5:1–10.