Methods

    • next generation sequencing/NGS (Illumina platform)  und microarray analysis (Agilent platform)
    • development and application of bioinformatic methods for the detection and analysis of viral agents by next generation sequencing or microarray analysis 
    • analysis of viral and cellular chromatin (ChIP-on-chip, ChIP-seq)
    • transcriptomics, analysis of transcription profiles via RNA-seq
    • all current molecular biology nucleic acids and protein methods
    • cultivation of established cell lines and primary cells
    • infection models of various Herpes- and Polyomaviruses
    • manipulation of complex viral genomes by bacmid technology
    • gene transfer by viral and non-viral systems
    • real-time PCR (DNA/ RNA)
    • fluorescence and light microscopy
    • FACS-analysis
    • Infection Model Systems of different Herpes- and Polyomaviruses

    Recent Publications

    Alawi M, Burkhardt L, Indenbirken D, Reumann K, Christopeit M, Kröger N, Lütgehetmann M, Aepfelbacher M, Fischer N, Grundhoff A (2019). DAMIAN: an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples. Sci Rep. 2019 Nov 14;9(1):16841.

    Bossler F, Kuhn BJ, Günther T, Kraemer SJ, Khalkar P, Adrian S, Lohrey C, Holzer A, Shimobayashi M, Dürst M, Mayer A, Rösl F, Grundhoff A, Krijgsveld J, Hoppe-Seyler K, Hoppe-Seyler F (2019). Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling. MBio. 2019 Feb 12;10(1).

    Chemnitz J, Pieper D, Stich L, Schumacher U, Balabanov S, Spohn M, Grundhoff A, Steinkasserer A, Hauber J, Zinser E (2019). The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice. Sci Rep. 2019 Mar 19;9(1):4853.